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All Publications

  • Moore, F.E.;Garcia, E.G.;Lobbardi, R.;Jain, E.;Tang, Q.;Moore, J.C.;Cortes, M.;Molodtsov, A.;Kasheta, M.;Luo, C.C.;Garcia, A.J.;Mylvaganam, R.;Yoder, J.A.;Blackburn, J.S.;Sadreyev, R.I.;Ceol, C.J.;North, T.E.;Langenau, D.M. “Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish.” The Journal of experimental medicine 213, 6 (2016): 979-92. [PubMed Link] | [Full Text]
  • Tang, Q.;Moore, J.C.;Ignatius, M.S.;Tenente, I.M.;Hayes, M.N.;Garcia, E.G.;Torres Yordán, N.;Bourque, C.;He, S.;Blackburn, J.S.;Look, A.T.;Houvras, Y.;Langenau, D.M. “Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish.” Nature communications 7,(2016): 10358. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Liu, S.;Wilder, J.L.;Dobrinski, K.P.;Lobbardi, R.;Moore, F.E.;Martinez, S.A.;Chen, E.Y.;Lee, C.;Langenau, D.M. “Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation.” Cancer cell 25, 3 (2014): 366-78. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Langenau, D.M. “Zebrafish as a model to assess cancer heterogeneity, progression and relapse.” Disease models & mechanisms 7, 7 (2014): 755-62. [PubMed Link] | [Full Text]
  • Tang, Q.;Abdelfattah, N.S.;Blackburn, J.S.;Moore, J.C.;Martinez, S.A.;Moore, F.E.;Lobbardi, R.;Tenente, I.M.;Ignatius, M.S.;Berman, J.N.;Liwski, R.S.;Houvras, Y.;Langenau, D.M. “Optimized cell transplantation using adult rag2 mutant zebrafish.” Nature methods 11, 8 (2014): 821-4. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Liu, S.;Raiser, D.M.;Martinez, S.A.;Feng, H.;Meeker, N.D.;Gentry, J.;Neuberg, D.;Look, A.T.;Ramaswamy, S.;Bernards, A.;Trede, N.S.;Langenau, D.M. “Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.” Leukemia 26, 9 (2012): 2069-78. [PubMed Link] | [Full Text]
  • Ignatius, M.S.;Chen, E.;Elpek, N.M.;Fuller, A.Z.;Tenente, I.M.;Clagg, R.;Liu, S.;Blackburn, J.S.;Linardic, C.M.;Rosenberg, A.E.;Nielsen, P.G.;Mempel, T.R.;Langenau, D.M. “In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma.”Cancer cell 21, 5 (2012): 680-93. [PubMed Link] | [Full Text]
  • Zheng, S.;Ghitani, N.;Blackburn, J.S.;Liu, J.P.;Zeitlin, S.O. “A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin’s polyglutamine stretch on CAG140 mouse model pathogenesis.” Molecular brain 5, (2012): 28. [PubMed Link] | [Full Text]
  • Moore, F.E.;Reyon, D.;Sander, J.D.;Martinez, S.A.;Blackburn, J.S.;Khayter, C.;Ramirez, C.L.;Joung, J.K.;Langenau, D.M. “Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs).” PloS one 7, 5 (2012): e37877. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Liu, S.;Langenau, D.M. “Quantifying the frequency of tumor-propagating cells using limiting dilution cell transplantation in syngeneic zebrafish.” Journal of visualized experiments : JoVE 53(2011): e2790. [PubMed Link] | [Full Text]
  • Sander, J.D.;Dahlborg, E.J.;Goodwin, M.J.;Cade, L.;Zhang, F.;Cifuentes, D.;Curtin, S.J.;Blackburn, J.S.;Thibodeau-Beganny, S.;Qi, Y.;Pierick, C.J.;Hoffman, E.;Maeder, M.L.;Khayter, C.;Reyon, D.;Dobbs, D.;Langenau, D.M.;Stupar, R.M.;Giraldez, A.J.;Voytas, D.F.;Peterson, R.T.;Yeh, J.R.;Joung, J.K.“Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA).” Nature methods 8, 1 (2011): 67-9. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Liu, S.;Raimondi, A.R.;Ignatius, M.S.;Salthouse, C.D.;Langenau, D.M. “High-throughput imaging of adult fluorescent zebrafish with an LED fluorescence macroscope.” Nature protocols 6, 2(2011): 229-41. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Langenau, D.M. “aMAZe-ing tools for mosaic analysis in zebrafish.” Nature methods 7, 3(2010): 188-90. [PubMed Link] | [Full Text]
  • Smith, A.C.;Raimondi, A.R.;Salthouse, C.D.;Ignatius, M.S.;Blackburn, J.S.;Mizgirev, I.V.;Storer, N.Y.;Jong, J.L.;Chen, A.T.;Zhou, Y.;Revskoy, S.;Zon, L.I.;Langenau, D.M. “High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia.” Blood 115, 16 (2010): 3296-303. [PubMed Link] | [Full Text]
  • Eck, S.M.;Blackburn, J.S.;Schmucker, A.C.;Burrage, P.S.;Brinckerhoff, C.E. “Matrix metalloproteinase and G protein coupled receptors: co-conspirators in the pathogenesis of autoimmune disease and cancer.” Journal of autoimmunity 33, 3-4 (2009): 214-21. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Brinckerhoff, C.E. “Wild-type versus mutant MMP-8 in melanoma: ‘when you come to a fork in the road, take it’.” Pigment cell & melanoma research 22, 3 (2009): 248-50. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Liu, I.;Coon, C.I.;Brinckerhoff, C.E. “A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis.” Oncogene 28, 48 (2009): 4237-48. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Brinckerhoff, C.E. “Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis.” The American journal of pathology173, 6 (2008): 1736-46. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Rhodes, C.H.;Coon, C.I.;Brinckerhoff, C.E. “RNA interference inhibition of matrix metalloproteinase-1 prevents melanoma metastasis by reducing tumor collagenase activity and angiogenesis.” Cancer research 67, 22 (2007): 10849-58. [PubMed Link] | [Full Text]