B.S. Centre College
M.S. University of Kentucky
Project: Modeling oncogenic chromosomal translocations using CRISPR/Cas9 gene editing
The goal of this project is to recreate chromosomal translocation events commonly found in pediatric cases of acute lymphoblastic leukemia using zebrafish as a model organism. We are using CRISPR/Cas9 gene editing technology to produce these translocations with the intent to optimize a streamlined protocol.
Meghan Green Haney
B.S. Denison University
Project: Identifying novel therapeutics to inhibit leukemia stem cell self-renewal pathways
My current research focuses on leukemia stem cell signaling and self-renewal pathways. Leukemia stem cells make up a very small population of leukemia cells and are responsible for leukemia relapse in vivo. We are looking at the signaling pathways in these stem cells trying to find drug targets to block self-renewal of these cells. We are using zebrafish as a model organism as they allow for in vivo study of leukemia stem cells and large volume drug screens.
Paul Laurence Dunbar High School