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Learn about what we have been working on, find out what we are interested in, and see our accomplishments!

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My name is John Blair, I am a senior at Paul Laurence Dunbar High School and the Math Science Technology Center in Lexington, KY.  This school year, I conducted research at the University of Kentucky.  During my time at the Blackburn Lab, I helped transform various mutations of the PRL-3 protein as part of the…

I had a great time in Jessi’s lab this summer! I was able to learn a variety of techniques and protocols through all of the amazing people there! One such technique was embryo injections into the eggs of zebrafish. I injected a mixture that would induce cancer in zebrafish that did not have PRL-3. In…

    Our lab studies the human prenylated protein tyrosine phosphatase PRL3 and its role in promoting metastatic activity in cancer. My project is more specifically focused on the mechanisms of PRL3 regulation. The current work is focused on how the post-translational modification profile of PRL3 impacts a metastatic phenotype. By over expressing PRL3 in…

Recent Publications

Read our most recent papers.

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A major goal of our lab’s PRL-3 projects is to find a way to inhibit PRL-3 activity. PRL-3 is essential for the growth and spread of many types of cancer, so if we can find a way to block PRL-3, we could potentially impact many patients. However, the drugs used to target PRL-3 are still…

Meghan and Henry have starred in a JoVE (Journal of Visualized Experiments) video article explaining how the lab transplants human cancer cells into zebrafish and uses them for high-throughput drug screening. The benefit of this xenograft model is that we can rapidly screen though hundreds of compounds in living animals, which allows us to find…

The lab’s first research manuscript is out! Min’s research defined the oncogenic role of PRL-3 phosphatase in T-cell acute lymphoblastic leukemia (T-ALL), which is a very progressive pediatric cancer and lacks targeted therapies. Our findings show that PRL-3 promotes T-ALL development/onset in zebrafish models and plays a role in engraftment in mouse xenograft models. Cell-culture…

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