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In October 2023 me and Jessi had the chance to go to Durham-North Carolina to attend the 16th Zebrafish Disease Models Society annual meeting. This meeting brings together researchers using zebrafish to model different human diseases. Research findings from the fields of cancer, skeletal muscle diseases, inflammation, gastrointestinal diseases and others were presented. Presenters shared…

During 2023 I worked in Blackburn Lab as visiting scholar and I had an amazing experience. I am professor in Brazil and during this year, I made a training to work with oncology research using zebrafish as animal model. I was involved in many projects which allowed me to go far beyond my expectations. My…

-Trace Jolly, University of Kentucky, Blackburn Lab The Blackburn lab uses zebrafish to study a variety of pediatric cancers. Our lab does this through two main techniques: 1-Transplants and 2- Transgenic Models. Zebrafish transplants/engraftments are a valuable model for examining how cells derived from an external source behave when implanted into a living organism. This…

Recent Publications

Read our most recent papers.

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The Wnt/β-catenin pathway is important in cancer and stem cell biology, making it a potential target for therapy. However, using Wnt inhibitors in the clinic is difficult due to off-target effects and interactions with other pathways. In this study, we used a zebrafish model to screen 773 FDA-approved drugs to find Wnt/β-catenin inhibitors with low…

Immunofluorescent microscopy allows us to see where proteins are located and how much of them are present in cells. The location of a protein in a cell can affect its function because certain interactions happen in specific areas. This article explains how to use immunofluorescent microscopy to identify phosphatases in cells. Finding out where and…

Phosphatase of regenerating liver 3 (PRL-3) is linked to cancer metastasis and interacts with the cyclin and CBS domain divalent metal cation transport mediator (CNNM) family of proteins to manage the levels of magnesium and other metals within cells. Despite its significance in cancer, the factors that regulate PRL-3’s activity and its interactions with CNNM…

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