Phosphatase of Regenerating Liver-3 (PRL-3) is associated with the progression and spread of cancer, but the limited number of research tools available to study this protein have prevented us from fully understanding of PRL-3's role in cancer. To address…
The increasing number of anti-cancer drugs poses a challenge for doctors who need to choose the best treatment for patients. Precision cancer medicine aims to match a drug with a tumors unique characteristics to maximize its effectiveness. However, current approaches…
Acute Lymphoblastic Leukemia (ALL) is a common type of cancer primarily affecting children. Unfortunately, patients who experience a relapse of ALL tend to have a poor prognosis. Detecting any remaining cancer cells, called minimal residual disease (MRD), and identifying its…
Nanopore sequencing is a new way to read the information stored in our DNA. The sequences of DNA can be determined by passing DNA strands through tiny pores and measuring the changes in electrical current as each DNA base passes…
A major goal of our lab's PRL-3 projects is to find a way to inhibit PRL-3 activity. PRL-3 is essential for the growth and spread of many types of cancer, so if we can find a way to block PRL-3,…
Meghan and Henry have starred in a JoVE (Journal of Visualized Experiments) video article explaining how the lab transplants human cancer cells into zebrafish and uses them for high-throughput drug screening. The benefit of this xenograft model is that we…
The lab's first research manuscript is out! Min's research defined the oncogenic role of PRL-3 phosphatase in T-cell acute lymphoblastic leukemia (T-ALL), which is a very progressive pediatric cancer and lacks targeted therapies. Our findings show that PRL-3 promotes T-ALL…
The first research paper from the lab has been published! This project was done by our high schooler (who is now killing it at Harvard) Shea Hausman, in collaboration with Chunming Liu's and Dave Watt's groups at UK. They made…
Min has the first paper from the lab! She wrote a very nice review on "Targeting Phosphatases of Regenerating Liver (PRLs) in Cancer" at the request of the editor of Pharmacology & Therapeutics. You can read it here. We worked…
Tox Regulates Growth, DNA Repair, and Genomic Instability in T cell Acute Lymphoblastic Leukemia