A major goal of our lab's PRL-3 projects is to find a way to inhibit PRL-3 activity. PRL-3 is essential for the growth and spread of many types of cancer, so if we can find a way to block PRL-3,…
Meghan and Henry have starred in a JoVE (Journal of Visualized Experiments) video article explaining how the lab transplants human cancer cells into zebrafish and uses them for high-throughput drug screening. The benefit of this xenograft model is that we…
The lab's first research manuscript is out! Min's research defined the oncogenic role of PRL-3 phosphatase in T-cell acute lymphoblastic leukemia (T-ALL), which is a very progressive pediatric cancer and lacks targeted therapies. Our findings show that PRL-3 promotes T-ALL…
The first research paper from the lab has been published! This project was done by our high schooler (who is now killing it at Harvard) Shea Hausman, in collaboration with Chunming Liu's and Dave Watt's groups at UK. They made…
Min has the first paper from the lab! She wrote a very nice review on "Targeting Phosphatases of Regenerating Liver (PRLs) in Cancer" at the request of the editor of Pharmacology & Therapeutics. You can read it here. We worked…
Tox Regulates Growth, DNA Repair, and Genomic Instability in T cell Acute Lymphoblastic Leukemia
Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation
Imaging tumor cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish
Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish