Methods for high-throughput drug screens of human cancer cells in zebrafish. JoVE, 2020

Meghan and Henry have starred in a JoVE (Journal of Visualized Experiments) video article explaining how the lab transplants human cancer cells into zebrafish and uses them for high-throughput drug screening. The benefit of this xenograft model is that we can rapidly screen though hundreds of compounds in living animals, which allows us to find drugs that kill the cancer cells but leave the animals healthy. In this video, they used Acute Lymphoblastic Leukemia cells isolated from a patient and then put in fish, and found drugs that the leukemia responds well to!

Read the protocol here J Vis Exp, 10(158), 2020, and check out the video below!