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Recent Publications

Discovery of semi-synthetic aurones that act as anti-cancer drugs. Scientific Reports, 2019

The first research paper from the lab has been published! This project was done by our high schooler (who is now killing it at Harvard) Shea Hausman, in collaboration with Chunming Liu’s and Dave Watt’s groups at UK. They made…

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Wei et al. Pharmacolgy & Therapeutics, 2018

Min has the first paper from the lab! She wrote a very nice review on “Targeting Phosphatases of Regenerating Liver (PRLs) in Cancer” at the request of the editor of Pharmacology & Therapeutics. You can read it here. We worked…

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Lobbardi et al. Cancer Discovery 2017

Tox Regulates Growth, DNA Repair, and Genomic Instability in T cell Acute Lymphoblastic Leukemia

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All Publications

  • Moore, F.E.;Garcia, E.G.;Lobbardi, R.;Jain, E.;Tang, Q.;Moore, J.C.;Cortes, M.;Molodtsov, A.;Kasheta, M.;Luo, C.C.;Garcia, A.J.;Mylvaganam, R.;Yoder, J.A.;Blackburn, J.S.;Sadreyev, R.I.;Ceol, C.J.;North, T.E.;Langenau, D.M. “Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish.” The Journal of experimental medicine 213, 6 (2016): 979-92. [PubMed Link] | [Full Text]
  • Tang, Q.;Moore, J.C.;Ignatius, M.S.;Tenente, I.M.;Hayes, M.N.;Garcia, E.G.;Torres Yordán, N.;Bourque, C.;He, S.;Blackburn, J.S.;Look, A.T.;Houvras, Y.;Langenau, D.M. “Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish.” Nature communications 7,(2016): 10358. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Liu, S.;Wilder, J.L.;Dobrinski, K.P.;Lobbardi, R.;Moore, F.E.;Martinez, S.A.;Chen, E.Y.;Lee, C.;Langenau, D.M. “Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation.” Cancer cell 25, 3 (2014): 366-78. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Langenau, D.M. “Zebrafish as a model to assess cancer heterogeneity, progression and relapse.” Disease models & mechanisms 7, 7 (2014): 755-62. [PubMed Link] | [Full Text]
  • Tang, Q.;Abdelfattah, N.S.;Blackburn, J.S.;Moore, J.C.;Martinez, S.A.;Moore, F.E.;Lobbardi, R.;Tenente, I.M.;Ignatius, M.S.;Berman, J.N.;Liwski, R.S.;Houvras, Y.;Langenau, D.M. “Optimized cell transplantation using adult rag2 mutant zebrafish.” Nature methods 11, 8 (2014): 821-4. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Liu, S.;Raiser, D.M.;Martinez, S.A.;Feng, H.;Meeker, N.D.;Gentry, J.;Neuberg, D.;Look, A.T.;Ramaswamy, S.;Bernards, A.;Trede, N.S.;Langenau, D.M. “Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.” Leukemia 26, 9 (2012): 2069-78. [PubMed Link] | [Full Text]
  • Ignatius, M.S.;Chen, E.;Elpek, N.M.;Fuller, A.Z.;Tenente, I.M.;Clagg, R.;Liu, S.;Blackburn, J.S.;Linardic, C.M.;Rosenberg, A.E.;Nielsen, P.G.;Mempel, T.R.;Langenau, D.M. “In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma.”Cancer cell 21, 5 (2012): 680-93. [PubMed Link] | [Full Text]
  • Zheng, S.;Ghitani, N.;Blackburn, J.S.;Liu, J.P.;Zeitlin, S.O. “A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin’s polyglutamine stretch on CAG140 mouse model pathogenesis.” Molecular brain 5, (2012): 28. [PubMed Link] | [Full Text]
  • Moore, F.E.;Reyon, D.;Sander, J.D.;Martinez, S.A.;Blackburn, J.S.;Khayter, C.;Ramirez, C.L.;Joung, J.K.;Langenau, D.M. “Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs).” PloS one 7, 5 (2012): e37877. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Liu, S.;Langenau, D.M. “Quantifying the frequency of tumor-propagating cells using limiting dilution cell transplantation in syngeneic zebrafish.” Journal of visualized experiments : JoVE 53(2011): e2790. [PubMed Link] | [Full Text]
  • Sander, J.D.;Dahlborg, E.J.;Goodwin, M.J.;Cade, L.;Zhang, F.;Cifuentes, D.;Curtin, S.J.;Blackburn, J.S.;Thibodeau-Beganny, S.;Qi, Y.;Pierick, C.J.;Hoffman, E.;Maeder, M.L.;Khayter, C.;Reyon, D.;Dobbs, D.;Langenau, D.M.;Stupar, R.M.;Giraldez, A.J.;Voytas, D.F.;Peterson, R.T.;Yeh, J.R.;Joung, J.K.“Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA).” Nature methods 8, 1 (2011): 67-9. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Liu, S.;Raimondi, A.R.;Ignatius, M.S.;Salthouse, C.D.;Langenau, D.M. “High-throughput imaging of adult fluorescent zebrafish with an LED fluorescence macroscope.” Nature protocols 6, 2(2011): 229-41. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Langenau, D.M. “aMAZe-ing tools for mosaic analysis in zebrafish.” Nature methods 7, 3(2010): 188-90. [PubMed Link] | [Full Text]
  • Smith, A.C.;Raimondi, A.R.;Salthouse, C.D.;Ignatius, M.S.;Blackburn, J.S.;Mizgirev, I.V.;Storer, N.Y.;Jong, J.L.;Chen, A.T.;Zhou, Y.;Revskoy, S.;Zon, L.I.;Langenau, D.M. “High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia.” Blood 115, 16 (2010): 3296-303. [PubMed Link] | [Full Text]
  • Eck, S.M.;Blackburn, J.S.;Schmucker, A.C.;Burrage, P.S.;Brinckerhoff, C.E. “Matrix metalloproteinase and G protein coupled receptors: co-conspirators in the pathogenesis of autoimmune disease and cancer.” Journal of autoimmunity 33, 3-4 (2009): 214-21. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Brinckerhoff, C.E. “Wild-type versus mutant MMP-8 in melanoma: ‘when you come to a fork in the road, take it’.” Pigment cell & melanoma research 22, 3 (2009): 248-50. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Liu, I.;Coon, C.I.;Brinckerhoff, C.E. “A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis.” Oncogene 28, 48 (2009): 4237-48. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Brinckerhoff, C.E. “Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis.” The American journal of pathology173, 6 (2008): 1736-46. [PubMed Link] | [Full Text]
  • Blackburn, J.S.;Rhodes, C.H.;Coon, C.I.;Brinckerhoff, C.E. “RNA interference inhibition of matrix metalloproteinase-1 prevents melanoma metastasis by reducing tumor collagenase activity and angiogenesis.” Cancer research 67, 22 (2007): 10849-58. [PubMed Link] | [Full Text]