Undergraduate Summer Recap 2021
I had a great time in Jessi’s lab this summer! I was able to learn a variety of techniques and protocols through all of the amazing people there! One such technique was embryo injections into the eggs of zebrafish. I…
Post-Translational Modifications of PRL3
Our lab studies the human prenylated protein tyrosine phosphatase PRL3 and its role in promoting metastatic activity in cancer. My project is more specifically focused on the mechanisms of PRL3 regulation. The current work is focused on how…
New Methods for Examining Nanobody Specificity and Binding to PRL-3
At our last lab meeting, I updated everyone on my project that has thus far focused on designing nanobodies, derived from alpaca heavy-chain only antibodies, that specifically bind to PRL-3. One of the biggest caveats to studying PRL-3 is the…
Methods for high-throughput drug screens of human cancer cells in zebrafish. JoVE, 2020
Meghan and Henry have starred in a JoVE (Journal of Visualized Experiments) video article explaining how the lab transplants human cancer cells into zebrafish and uses them for high-throughput drug screening. The benefit of this xenograft model is that we…
The Lab to the Red Carpet
Hello everyone! So something cool that Meghan and I were recently tasked with was starring in a movie! By publishing through JOVE, we were filmed performing the different methods and procedures we used to xenograft primary patient samples into zebrafish…
The phosphatase PRL-3 drives ALL progression, Oncogenesis 2020
The lab's first research manuscript is out! Min's research defined the oncogenic role of PRL-3 phosphatase in T-cell acute lymphoblastic leukemia (T-ALL), which is a very progressive pediatric cancer and lacks targeted therapies. Our findings show that PRL-3 promotes T-ALL…
Min goes to the ASH!
Min attended ASH, the American Society of Hematology annual meeting, which is the major hematology meeting each year that thousands of clinicians and scientists attend. Min presented a poster on the role of PRL-3 in Acute Lymphoblastic Leukemia onset and…
❤ Kristin Got Married! ❤
Caroline and I were so excited to attend Kristin's wedding at her hometown in Edmonton KY this weekend! She looked really pretty and she and Michael were both smiling non-stop the entire time. Her mom was really cute, and excited to…
A successful summer in the Blackburn lab!
My name is Tyler Sullivan and I am a senior chemistry student at Morehead State University. Working in the Blackburn lab as part of the KBRIN program has been one of the most exciting experiences of my career. The environment was…
Gordon Conference on Wnt Signaling
This summer I had the chance to attend a Gordon Conference on Wnt signaling in Mount Snow, Vermont! It was a great experience to be able to attend a smaller conference and network with people in the field. I presented…