Despite advancements in treatment, T-cell acute lymphoblastic leukemia (T-ALL) remains difficult to cure when it relapses, largely due to leukemia stem cells (LSCs), a small but powerful group of cells that resist therapy and restart the disease. Using a zebrafish…
Pediatric sarcomas, like osteosarcoma and Ewing’s sarcoma, are aggressive cancers that are difficult to treat, especially when they return after initial therapy. Right now, doctors often rely on trial-and-error to determine which treatments might work, a process that takes time…
Every child’s tumor is unique, and genetic sequencing can help identify potential treatment options. However, predicting which drugs will actually work remains a major challenge. This project, funded by the Kentucky Pediatric Cancer Research Trust Fund, will integrate zebrafish patient-derived…