Targeting mitochondria to stop leukemia stem cell self-renewal. Cancer Biology & Therapy (2025)

In T-cell acute lymphoblastic leukemia (T-ALL), a rare but aggressive childhood cancer, some leukemia cells—called leukemia stem cells (LSCs)—can evade chemotherapy and cause relapse. Majd’s review explores an exciting new approach: targeting mitochondria, the powerhouses of cells, to eliminate these stubborn LSCs. With mitochondrial-targeting drugs (mitocans) already in early clinical trials, unlocking their potential could revolutionize T-ALL treatment and improve survival for children battling this disease.

Check it out here: https://pmc.ncbi.nlm.nih.gov/articles/PMC11801350/