The PACT Network: PRL, ARL, CNNM, and TRPM Proteins in Magnesium Transport and Disease, International Journal of Molecular Sciences (2025)

Magnesium is essential for many cellular functions, and its balance is tightly controlled to prevent disease. Trace’s review highlights an emerging network of proteins—PRL, ARL, CNNM, and TRPM (collectively termed PACT)—that work together to regulate magnesium levels. By understanding how these proteins interact, we can uncover new strategies for treating diseases linked to magnesium imbalance, including cancer.

AND, our paper was chosen as the cover for IJMS! Check it out here: https://www.mdpi.com/1422-0067/26/4/1528