Tracking leukemia stem cells in zebrafish with fluorescent staining, Journal of Visualized Experiments (2024)

Majd and Yelena’s study explores how some leukemia stem cells (LSCs) in T-cell acute lymphoblastic leukemia (T-ALL) become dormant, allowing them to evade chemotherapy and cause relapse. Using zebrafish models, they optimized a method to label and track these slow-dividing, treatment-resistant cells with fluorescent dyes. Filming the video protocol for this method for JoVE was a blast, and we’re excited to share this approach to help researchers better understand and target these relapse-driving leukemia cells!

https://pmc.ncbi.nlm.nih.gov/articles/PMC11806935/