Zebrafish Avatars for Predicting Sarcoma Treatment Responses
Pediatric sarcomas, like osteosarcoma and Ewing’s sarcoma, are aggressive cancers that are difficult to treat, especially when they return after initial therapy. Right now, doctors often rely on trial-and-error to determine which treatments might work, a process that takes time…
Sam’s summer with the lab
I worked with Dr. Blackburn this summer through the Markey STRONG program. My project’s scope focused primarily on the radioresistance associated with missense mutations in TP53, and how those mutations (uniquely) collaborate with the H3K27M mutation found in 80% of…
Maddie’s summer recap!
This summer, I had the opportunity to work in the Blackburn Lab through the Kentucky INBRE Summer Research Program. I investigated Deferoxamine as a drug therapy to prevent relapse in patients with T-cell Acute Lymphoblastic Leukemia. It was an invaluable…
Tracking leukemia stem cells in zebrafish with fluorescent staining, Journal of Visualized Experiments (2024)
Majd and Yelena’s study explores how some leukemia stem cells (LSCs) in T-cell acute lymphoblastic leukemia (T-ALL) become dormant, allowing them to evade chemotherapy and cause relapse. Using zebrafish models, they optimized a method to label and track these slow-dividing,…
