In T-cell acute lymphoblastic leukemia (T-ALL), a rare but aggressive childhood cancer, some leukemia cells—called leukemia stem cells (LSCs)—can evade chemotherapy and cause relapse. Majd’s review explores an exciting new approach: targeting mitochondria, the powerhouses of cells, to eliminate these…
Magnesium is essential for many cellular functions, and its balance is tightly controlled to prevent disease. Trace's review highlights an emerging network of proteins—PRL, ARL, CNNM, and TRPM (collectively termed PACT)—that work together to regulate magnesium levels. By understanding how…
Majd and Yelena’s study explores how some leukemia stem cells (LSCs) in T-cell acute lymphoblastic leukemia (T-ALL) become dormant, allowing them to evade chemotherapy and cause relapse. Using zebrafish models, they optimized a method to label and track these slow-dividing,…
The Wnt/β-catenin pathway is important in cancer and stem cell biology, making it a potential target for therapy. However, using Wnt inhibitors in the clinic is difficult due to off-target effects and interactions with other pathways. In this study, we…
Immunofluorescent microscopy allows us to see where proteins are located and how much of them are present in cells. The location of a protein in a cell can affect its function because certain interactions happen in specific areas. This article…
Phosphatase of regenerating liver 3 (PRL-3) is linked to cancer metastasis and interacts with the cyclin and CBS domain divalent metal cation transport mediator (CNNM) family of proteins to manage the levels of magnesium and other metals within cells. Despite…
Phosphatase of Regenerating Liver-3 (PRL-3) is associated with the progression and spread of cancer, but the limited number of research tools available to study this protein have prevented us from fully understanding of PRL-3's role in cancer. To address…
The increasing number of anti-cancer drugs poses a challenge for doctors who need to choose the best treatment for patients. Precision cancer medicine aims to match a drug with a tumors unique characteristics to maximize its effectiveness. However, current approaches…
Acute Lymphoblastic Leukemia (ALL) is a common type of cancer primarily affecting children. Unfortunately, patients who experience a relapse of ALL tend to have a poor prognosis. Detecting any remaining cancer cells, called minimal residual disease (MRD), and identifying its…
Nanopore sequencing is a new way to read the information stored in our DNA. The sequences of DNA can be determined by passing DNA strands through tiny pores and measuring the changes in electrical current as each DNA base passes…